We are all conscious of the point that slimming is actually a mega-dollar industry. With millions, or else millions of people of all ages struggling to shed weight, and very few pharmaceutically effective medications open to assist them, the desperate public will literally clutch at straws.
Weekly sees the launch of any new “miracle” diet pill or potion and a “surefire” diet certain to help believers shed kilos like magic.
Recently dr oz and garcinia cambogia became the flavour of year. If you search the internet for information about this exotic fruit extract you may be assured that the is finally the miracle many of us have been awaiting, that can produce dramatic fat loss. Endorsements by various TV personalities and other luminaries have included in the allure of Garcinia cambogia slimming products.
As outlined by a recent local study through the Tshwane University of Technology (TUT) “this small fruit, reminiscent of a pumpkin in looks, happens to be most popularly used and widely advertised as a weight-loss supplement”.
The comprehensive overview from TUT shows that research indicates that “the extracts as well as (-)-hydroxycitric acid (HCA), a primary organic acid part of the fruit rind, exhibited anti-obesity activity”. It also regulates the serotonin levels associated with satiety, leading to reduced intake of food.
“Based on clinical trial reports, Garcinia extracts were good for obese individuals most of the time. Additionally, studies in the toxicity and observations during numerous studies indicate that Garcinia is safe for use. Most of the negative reports have already been relevant to times when multi ingredient formulations were consumed and the effect could stop being attributed to a certain ingredient.”
The studies does, however, caution against an increase in serotonin, particularly in people who take medicines that happen to be already increasing serotonin levels, for example SSRIs. Research into these effects has not been conducted.
“Moreover, regulatory authorities should provide and enforce legislation requiring the compulsory basic safety demonstration of supplements pre-marketing and develop post-marketing surveillance systems,” the study concluded.
Dr Ingrid van Heerden, an authorized dietitian, is of opinion that people needs to be cautious of cambogia garcinia, simply because it has not yet undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once a person who wants, or needs to shed weight, is hooked on the promise of a slim, sexy figure, they are sucked in to the deception. When the drops, wafers or powders don’t work, well then it is the fault in the user who did not adhere to one or another often impossible instruction such as “stick to a 500 kcal/day diet” or “drink 5 litres water a day”, never that from the diet plan pill.
When eventually science and legislation meet up with the makers, they calmly take product A off of the market, change their formulation slightly, modify the name to product B, and then blithely sell product B utilizing the same advertising gambits as before, raking from the money and pulling the wool over everyone’s eyes once again.
Consistent with the ever-changing slimming product ranges, you can find what one can call “ingredients of the season” (sometimes an ingredient will last for only three to six months, however, many have longer life spans, after which obviously some are resurrected every two to three years).
We certainly have had apple cider vinegar (which contains made many a comeback through the years), green tea extract (which includes earned some merit in research studies), hoodia (which just will not find a way to make the research results that can make it a front-runner), willow bark (or salicylic acid which will work for pains and aches but not as efficacious for slimming), and traditional caffeine (that has a diuretic effect thus assisting you slim down till you replenish the liquid within your body, as well as a stimulant effect when taken in big amounts that can be potentially dangerous), to mention but a couple of.
Even though it is perfectly likely that more extensive and well controlled scientific tests will reveal that this extract of Garcinia cambogia containing a chemical called hydroxycitric acid (HCA) will help fat loss, we have been at the moment not sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it may or may not have and what dosage is required to achieve really significant weight-loss.
Nevertheless I hear you say: “For once there exists a variety of scientific research that had been performed with Garcinia cambogia, so what’s the problem?”
Well some of the studies did not show any fat loss differences between patients who took Garcinia pills and those who took dummy pills, while other studies did show variations in weight loss together with the subjects taking pills containing Garcinia losing a little more weight as opposed to those that did not (Marquez et al, 2012).
Some of these weight loss differences were not really exciting either, so that we can’t say for sure that Garcinia cambogia does promote fat loss. Furthermore, it seems likely that this may not be the wonder pill it is made in the market to be.
In addition, most of the studies conducted so far are already flawed (Critchley, 2013) . What that means is made for example that in a single study the control and experimental subjects were not well matched (i.e. they was without exactly the same starting weight, age, number of unwanted fat etc.), when in other studies too few subjects were utilised for that leads to be significant.
For your outcomes of studies to become plausible one has to compare “apples with apples” (i.e. well-matched subjects and controls) and also you need not only a handful of subjects to make the identical result.
About the positive side, we can easily state that there may be some evidence that Garcinia cambogia products may aid fat loss during a period of 12 weeks. No research has been conducted for longer periods as yet (Marquez et al, 2012), and this is viewed as a drawback.
Additionally there is at present an argument concerning the safety of pills containing Garcinia cambogia – one selection of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez along with his coworkers (2012) suggest that “at the doses usually administered, no differences have already been reported in terms of negative effects or adverse events (those studied) in humans between individuals treated with G. cambogia and controls.”
Ano Lob (2009), a public health consultant in the states has published a stern warning about the hepatotoxicity of a weight loss product called “Hydroxycut”, containing Garcinia cambogia. The writer collected case reports of patients who developed liver toxicity of the above mentioned weight loss product.
Evidently approximately one million units on this hydroxycitric acid product are sold annually in the united states. The patients who developed hepatotoxicity reported symptoms of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the amount of hepatotoxicity cases reported were very few, Lob points out that monitoring of adverse events associated with nutritional supplements such as these weight reduction products is woefully inadequate in the united states (as is the situation in many other countries, including South Africa), together with the FDA only receiving about 1% of the negative reports.
Based on Lob (2009), the Poison Control Centres in the USA are more likely to receive reports of adverse events connected with vitamin supplements however they are not equipped to coordinate such findings.
He cites the truly sobering demonstration of a product called “Metabolife 356″ that has been sold as a diet supplement in the us. Lob’s states how the manufacturers received 14 000 reports over a period of five years that documented “serious adverse events linked to their ephedra-containing product” which dexrpky17 heart attacks, strokes, convulsions and fatalities.
The makers did not inform the FDA or some other US government authority of these reports. As astounding since this may seem, manufacturers of dietary supplements will not be necessary to meet some of the specifications which are strictly enforced when it comes to food and pharmaceutical products (medicines), to enable them to utilize this “ethical loophole” to never publish reports of negative and harmful events.
Eventually these events stumbled on light and ephedra-containing products for slimming as well as other uses were banned in the USA.
The implication contain in Lob’s warning is the fact HCA or Garcinia cambogia extract can also be potentially toxic unless sufficient, reliable evidence to the contrary is made available.
In the present moment, we have no idea enough about slimming products that contain warnings of garcinia cambogia to freely recommend its use. I tend to are in agreement with Astell and coworkers (2013) who conducted a systematic review of double blind randomised controlled clinical studies to gauge evidence available on the efficacy of current dietary supplements accustomed to control appetite and/or weight.
These authors figured that “According towards the finding out of this systematic review, evidence is not convincing in demonstrating that a majority of dietary supplements used as appetite suppressants for weight loss in the management of obesity are effective and safe.”
While we wait around for more extensive and conclusive evidence obtained with larger variety of well-matched test subjects treated for longer periods together with the “gold standard” of double blind randomised controlled clinical trials, rather avoid using any weight-loss supplement that has not been tested thoroughly.